METHOCEL™ K100M Premium (Low Nitrite Grade)

1 of 65 products in this brand
METHOCEL™ K100M Premium (Low Nitrite Grade) is a low nitrite grade of hydroxypropyl methylcellulose in powder form. It is used in the production of capsules and tablets through tablet coating and wet granulation processes. This product functions as an immediate release agent and is suitable for modified and controlled release applications in pharmaceutical and nutraceutical formulations.

Functions: Immediate Release Agent

Manufacturing Technology: Tablet Coating, Wet Granulation

Dosage Form: Capsules, Tablets

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Enhanced TDS

Identification & Functionality

Applications & Uses

Properties

Physical Form
Soluble In
Physical Properties
ValueUnitsTest Method / Conditions
pH (at 2%)5 - 8-Current USP/EP/JP
Typical Properties
ValueUnitsTest Method / Conditions
Residue on Ignitionmax. 1.5%Current USP/JP
Apparent Viscosity (at 20°C, 2% in water)75,000 - 140,000mPa.sCurrent USP/EP/JP Brookfield
Sulfated Ash Contentmax. 1.5%Current USP/EP/JP
Moisture Contentmax. 5%Current USP/EP/JP
Propylene Chlorohydrins Content*max. 0.1mg/kgE464/JECFA
Apparent Viscosity (target)100000mPa.s-
Nitrite Contentmax. 200μg/kgPSM 300040
Microbiological Values
ValueUnitsTest Method / Conditions
Salmonella*Absent/10gCurrent USP NEGATIVE
Pseudomonas aeruginosa*Absent/gCurrent USP NEGATIVE
Escherichia coli*Absent/gCurrent USP
Yeast and Mold Count*max. 100/gCurrent USP
Total Plate Count*max. 100/gCurrent USP
Staphylococcus aureus*Absent/gCurrent USP NEGATIVE
Composition
ValueUnitsTest Method / Conditions
Hydroxypropoxyl Content7 - 12%Current USP/EP/JP
Methoxyl Content19 - 24%Current USP/EP/JP
Residual Solvents
ValueUnitsTest Method / Conditions
Propylene Glycol Contentmax. 0.1%-
Dipropylene Glycol Contentmax. 0.1%-
Tripropylene Glycol Contentmax. 0.1%-
Dipropylene Glycol Monomethyl Ether Contentmax. 0.1%-
Tripropylene Glycol Monomethyl Ether Contentmax. 0.1%-
Heavy Metals
ValueUnitsTest Method / Conditions
Arsenic Content*max. 0.1mg/kgE464
Cadmium Content*max. 0.1mg/kgE464
Mercury Content*max. 0.1mg/kgE464
Lead Content*max. 0.1mg/kgE464
Note
  • PHS - All section names come under PHS
  • * Tests tagged or noted as "Audit Basis" [AB] are conducted on a frequency that is established for each test. Audit testing is justified by knowledge of the manufacturing process, process control, use of dedicated equipment and raw material specifications.

Regulatory & Compliance

Certifications & Compliance
Chemical Inventories

Packaging & Availability

Packaging Type