METHOCEL™ K100 Premium LV CR (Low Nitrite Grade)

1 of 65 products in this brand
METHOCEL™ K100 Premium LV CR (Low Nitrite Grade) is a low nitrite grade of hydroxypropyl methylcellulose in powder form. It is used in the production of capsules and tablets through tablet coating and wet granulation processes. This product functions as an immediate release agent in pharmaceutical and nutraceutical applications.

Functions: Immediate Release Agent

Manufacturing Technology: Tablet Coating, Wet Granulation

Dosage Form: Capsules, Tablets

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Enhanced TDS

Identification & Functionality

Applications & Uses

Properties

Physical Form
Physical Properties
ValueUnitsTest Method / Conditions
pH (at 2%)5 - 8-CURRENT USP/EP/JP
Typical Properties
ValueUnitsTest Method / Conditions
Moisture (Loss on Drying)max. 5.0%USP/EP/JP
Sulfated Ashmax. 1.5%CURRENT USP/EP/JP
Loss on Dryingmax. 5.0%CURRENT USP/EP/JP
Nitrite Contentmax. 200μg/kgPSM 300040
Residue on Ignitionmax. 1.5%USP/JP
Propylene Chlorohydrins*max. 0.1mg/kgE464
Apparent Viscosity (at 20°C, 2% in water)80 - 120mPa·sCURRENT USP/EP/JP, Brookfeild
Microbiological Values
ValueUnitsTest Method / Conditions
Apparent Viscosity (Target)100mPa.sTarget
E. coli*Absent/gUSP
Yeasts and Molds Countmax. 100/gCURRENT USP Total Count
Pseudomonas aeruginosa*Absent/gUSP
Total Plate Countmax. 100/gCURRENT USP Total Aerobic
Salmonella*Absent/10gUSP
Staphylococcus aureus*Absent/gUSP
Yeasts and Molds*max. 100/gUSP
Composition
ValueUnitsTest Method / Conditions
Hydroxypropoxyl Content7.5 - 9.5%CURRENT USP/EP/JP
Methoxyl Content22 - 24%CURRENT USP/EP/JP
Residual Solvents
ValueUnitsTest Method / Conditions
Propylene Glycolmax. 0.1%-
Dipropylene Glycolmax. 0.1%-
Tripropylene Glycolmax. 0.1%-
Dipropylene Glycol Monomethyl Ethermax. 0.1%-
Tripropylene Glycol Monomethyl Ethermax. 0.1%-
Heavy Metals
ValueUnitsTest Method / Conditions
Arsenic Content*max. 0.1mg/kgE464
Cadmium Content*max. 0.1mg/kgE464
Mercury Content*max. 0.1mg/kgE464
Lead Content*max. 0.1mg/kgE464
Screen Test
ValueUnitsTest Method / Conditions
Partcle Size (through 230 USS sieve, <63 micron)50.0 - 80.0%PSM 100669
Partcle Size (through 100 USS sieve, <149 micron)min. 90.0%PSM 100669
Partcle Size (through 40 USS sieve, <420 micron)min. 99.0%PSM 100669
Note
  • PHS - All section names come under PHS
  • * Tests tagged or noted as "Audit Basis" [AB] are conducted on a frequency that is established for each test. Audit testing is justified by knowledge of the manufacturing process, process control, use of dedicated equipment and raw material specifications.

Regulatory & Compliance