METHOCEL™ E5 Premium LV HPMC

1 of 65 products in this brand

METHOCEL™ E5 Premium LV HPMC is water-soluble and used in suspensions, granulation, and tablet coating. It functions as a binder, controlled release agent, film former, and gelling agent in pharmaceuticals and nutraceuticals, and as a binder in ceramics.

Functions: Binder, Controlled Release Agent, Emulsifier, Film Former, Gelling Agent, Immediate Release Agent, Lubricant (Internal), Mucoadhesive, Plasticizer, Rheology Modifier, Solubilizer, Surfactant, Sustained Release Agent, Thickener, Viscosity Modifier

Manufacturing Technology: Granulation, Tablet Coating

Dosage Form: Suspension, Tablets

Certifications & Compliance Search Terms: National Formulary (NF)

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Identification & Functionality

Chemical Family: Cellulose & Cellulosics,
Cellulose Ethers
Chemical Name: Hydroxypropyl Methylcellulose
INCI Name: Methylcellulose
Raw Material Origin: Plant Origin
Cosmetic Ingredients Functions: Thickener
Pharma & Nutraceuticals Functions: Binder,
Controlled Release Agent,
Film Former,
Gelling Agent,
Immediate Release Agent,
Mucoadhesive,
Solubilizer,
Sustained Release Agent,
Thickener,
Viscosity Modifier
Plastics & Elastomers Functions: Binder,
Emulsifier,
Film Former,
Lubricant (Internal),
Plasticizer,
Rheology Modifier,
Surfactant
Technologies: Cosmetic Ingredients,
Pharmaceuticals & Nutraceuticals
Product Families: Pharmaceuticals & Nutraceuticals — Excipients
Binders & Disintegrants,
Emulsifiers & Stabilizers,
Formulation & Processing Aids,
Modified & Controlled Release,
Pharmaceutical Coatings,
Solvents & Solubilizers
Cosmetic Ingredients — Functionals
Rheology Modifiers

Features & Benefits

Food Ingredients Features: Cold Water Dispersible
Materials Features: Anti-settling Properties,
Good Gelling Behaviour,
Good Thickening Properties,
Good pH Stability,
Improved Adhesion,
Non-Ionic,
Water Soluble,
Wide pH Range

Applications & Uses

Markets: Healthcare & Pharma,
Personal Care
Applications: Personal Care — Beauty & Care
Oral Care
Healthcare & Pharma — Drug Delivery & Care Solutions
Oral
Segments: Dietary Supplement,
Pharmaceutical
Applications: Pharmaceutical — Immediate release
Dietary Supplement — Immediate release
Application Format: Rinse Off
Dosage Form: Suspension,
Tablets
Manufacturing Technology: Granulation,
Tablet Coating
Oral Care Applications: Mouthwash,
Toothpaste

Properties

Physical Form

Soluble In

Cold Water Soluble,

Organic Solvent Soluble,

Propylene Glycol Soluble,

Physical Properties


	Value	Units	Test Method / Conditions
pH (at 2% solution)*	5.0 - 8.0		USP/EP/JP/CHP

Typical Properties


	Value	Units	Test Method / Conditions
Residue on Ignition	max. 1.5	%	USP/JP/CHP
Sulfated Ash	max. 1.5	%	CURRENT USP/EP/JP
Apparent Viscosity (2% in water, at 20°C)	4.0 - 6.0	mPa.s	CURRENT USP/EP/JP/CHP
Propylene Chlorohydrins [AB]	max. 0.1	mg/kg	E464/FCC/JECFA

Microbiological Values


	Value	Units	Test Method / Conditions
Yeast and Mold Count*	max. 100	/g	CURRENT USP
Total Plate Count*	max. 100	/g	CURRENT USP
Escherichia coli [AB]	Pass	/g	CURRENT USP NEGATIVE
Pseudomonas aeruginosa [AB]	Pass	/g	CURRENT USP NEGATIVE
Salmonella [AB]	Pass	/g	CURRENT USP NEGATIVE

Composition


	Value	Units	Test Method / Conditions
Methoxyl Content	28.0 - 30.0	%	USP/EP/JP/CHP
Hydroxypropoxyl Content	7.0 - 12.0	%	USP/EP/JP/CHP

Specifications


	Value	Units	Test Method / Conditions
Transmittance*	min. 79.0	%	CE-91.29
Moisture Content (Loss on Drying)*	max. 5.0	%	USP/EP/JP/CHP
Propylene Chlorohydrins	max. 0.1	mg/kg	E464
Water Insoluble Substances	max. 0.5	%	CHP

Heavy Metals


	Value	Units	Test Method / Conditions
Arsenic Content	max. 0.1	mg/kg	E464/CHP
Cadmium Content	max. 0.1	mg/kg	E464
Lead Content	max. 0.1	mg/kg	E464/FCC/JECFA
Heavy Metals [PC]	max. 10	mg/kg	CHP
Mercury Content	max. 0.1	mg/kg	E464

Note

*NF and Ph. Eur. ID tests; “A” and “B” on a quarterly basis. ID tests “C” (NF and Ph. Eur.) and “D” (Ph.Eur.) will be completed by exception only.

Regulatory & Compliance

Certifications & Compliance Search Terms: National Formulary (NF)
Chemical Inventories: AICS (Australia),
AIIC (Australia),
CSCL (Japan),
DSL (Canada),
EINECS (EU),
ENCS (Japan),
IECSC (China),
ISHL (Japan),
KECI (Korea),
METI (Japan),
NDSL (Canada),
PICCS (Phillipines),
TSCA (USA)
Quality Standards: EN ISO 9001:2015,
GMP,
ICH Q3D

Packaging & Availability

Packaging Type: Bags,
Boxes,
Drums,
Super Sacks