METHOCEL™ E4M Premium CR HPMC

1 of 65 products in this brand
METHOCEL™ E4M Premium CR HPMC is water-soluble and used in suspensions, granulation, and tablet coating. It serves as a binder, controlled release agent, film former, gelling agent, and immediate release agent in pharmaceuticals and nutraceuticals, and as a binder in ceramics.

Functions: Binder, Controlled Release Agent, Emulsifier, Film Former, Gelling Agent, Immediate Release Agent, Lubricant (Internal), Mucoadhesive, Plasticizer, Rheology Modifier, Solubilizer, Surfactant, Sustained Release Agent, Thickener, Viscosity Modifier

Manufacturing Technology: Granulation, Tablet Coating

Dosage Form: Suspension, Tablets

Certifications & Compliance Search Terms: National Formulary (NF)

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Enhanced TDS

Identification & Functionality

Features & Benefits

Applications & Uses

Properties

Physical Form
Soluble In
Physical Properties
ValueUnitsTest Method / Conditions
pH (at 2% solution)*5.0 - 8.0-USP/EP/JP/CHP
Typical Properties
ValueUnitsTest Method / Conditions
Water Insoluble Substances [PC] max. 0.5% CHP
Propylene Chlorohydrins [AB] max. 0.1mg/kgE464
Microbiological Values
ValueUnitsTest Method / Conditions
E. coli*Absent/gCurrent USP Negative
Pseudomonas aeruginosa*Absent/1gCurrent USP Negative
Salmonella*Absent/10gCurrent USP Negative
Staphylococcus aureus*Absent/gCurrent USP Negative
Yeast and Mold Count*max. 100/gCurrent USP Combined Mold And Yeast
Total Plate Count*max. 100/gCurrent USP Total Aerobic
Composition
ValueUnitsTest Method / Conditions
Hydroxypropoxyl Content*8.5 - 10.5%USP/EP/JP/CHP
Methoxyl Content*28.0 - 30.0%USP/EP/JP/CHP
Specifications
ValueUnitsTest Method / Conditions
Sulfated Ash Content*max. 1.5%Current USP/EP/JP
Loss on Drying*max. 5.0%USP/EP/JP/CHP
Residue on Ignition*max. 1.5%USP/JP/CHP
Apparent Viscosity (at 20°C, 2% in water)*2,663 - 4,970mPa.sUSP/EP/JP/CHP
Heavy Metals
ValueUnitsTest Method / Conditions
Lead Contentmax. 0.1 mg/kg E464
Arsenic Contentmax. 0.1 mg/kg E464/CHP
Cadmium Contentmax. 0.1 mg/kg E464
Mercury Contentmax. 0.1 mg/kg E464
Heavy Metals [PC]max. 10 mg/kg CHP
Screen Test
ValueUnitsTest Method / Conditions
Screen (< 149 micron, through 100 U.S. STD.Sieve)*min. 95.0%PSM 100669
Screen (< 420 micron, through 40 U. S. STD. Sieve)*min. 99.0%PSM 100669
Screen (<63 micron) 50.0 - 80.0 % PSM 100669 THRU 230 U.S.STD. SIEVE
Note

*PHS - All section names come under PHS
[AB] = Audit Basis

Regulatory & Compliance

Technical Details & Test Data

Nutritional Information
USA
Nutritional Information (per 100 g)
Carbohydrates (g) 0
Non-Digestible Carbohydrates (g) 93.5
Water (g) 5
Ash (g) (includes salt and iron) 1.5
Total Fat (g) 0
Saturated Fat (g) 0
Trans Fat (g) 0
Protein (g) 0

 

Additional Nutrient Information (per 100 g)
Calories (Energy) (kcal) 0
Cholesterol (mg) 0
Total Dietary Fiber (g) 0
Soluble Fiber (g) 93.5
Insoluble Fiber (g) 0
Sugars (g) 0
Added Sugars (g) 0
Sodium (mg) 390
Chloride (mg) 610
Potassium (mg) 0
Magnesium (mg) 0
Iron (mg) 15
Zinc (mg) 0
Total Vitamin A (IU) 0
Vitamin C (mg) 0
Thiamin (mg) 0
Riboflavin (mg) 0
Vitamin D (IU) 0
Niacin (mg) 0
Vitamin B6 (mg) 0
Calcium (mg) 0
Phosphorus (mg) 0

 

European Union
Nutritional Information (per 100 g)
Energy

748 kJ / 187 kcal

Fat 0 g
Of which saturates 0 g
Carbohydrates 0 g
Of which sugars 0 g
Fibre 93.5 g
Protein 0 g
Salt 1.5 g

 

Australia & New Zealand
Nutritional Information (per 100 g)
Energy (kJ) 748
Carbohydrates (g) 0
Dietary Fibre (g) 93.5
Water (g) 5
Ash (g) (includes salt and iron) 0.4
Total Fat (g) 0
Saturated Fat (g) 0
Trans Fat (g) 0
Protein (g) 0

Packaging & Availability