Microcrystalline Cellulose is purified, partially depolymerized cellulose prepared by treating alpha cellulose obtained as a pulp from fibrous plant material with mineral acids. Several grades of Avicel® PH MCC are available varying in particle size distribution, density and moisture content. Avicel® PH microcrystalline cellulose (MCC) is most often used as a filler, disintegrant, flow aid, and dry binder for tablets and capsules. Avicel® PH-200 has a typical average particle size of 200 µm and moisture content between 3 and 5%. Avicel® PH-200 is primarily used for direct compression, and dry granulation/roller compaction. Larger particle size of Avicel® PH-200 provides enhanced flow characteristics. When compressed, Avicel® PH MCC undergoes plastic deformation. The strength of MCC tablets results from hydrogen bonding between the plastically deformed, large surface area cellulose particles. MCC is recognized as the most compactable of any direct compression excipient.

Chemical Name: Cellulose, Microcrystalline

CAS Number: 9004-34-6

Dosage Form: Capsules, Effervescent Tablets, Granules, Orally Disintegrating Tablets (ODTs), Pellets, Tablets

Manufacturing Technology: Direct Compression, Dry Granulation, Wet Granulation

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Enhanced TDS

Identification & Functionality

Applications & Uses

Properties

Physical Form
Soluble in
Copper Tetrammine Hydroxide
Physico-Chemical Properties
ValueUnitsTest Method / Conditions
Loss on Drying (More restrictive than compendium)2.0 - 5.0%-
Bulk Density0.29 - 0.36g/cc-
Identification (A,B)Pass--
Degree of Polymerizationmax. 350units-
pH (More restrictive than compendium)5.5 - 7.0--
Conductivitymax. 75μS/cm-
Residue on Ignitionmax. 0.05%-
Water Soluble Substancesmax. 12.5mg/5g-
Water Soluble Substancesmax. 0.25%-
Ether Soluble Substancesmax. 5.0mg/10g-
Heavy Metalsmax. 0.001%-
Microbiological Values
ValueUnitsTest Method / Conditions
Total Aerobic Microbial Count (More restrictive than compendium)max. 100cfu/g-
Yeast and Mold Count (Total, More restrictive than compendium)max. 20cfu/g-
Pseudomonas aeruginosaAbsent/10g-
E. coliAbsent/10g-
Staphylococcus aureusAbsent/10g-
Salmonella SpeciesAbsent/10g-
Coliform SpeciesAbsent/10g-
Particle Size Distribution
ValueUnitsTest Method / Conditions
Particle Size (D10)0 - 175--
Particle Size (D50)142 - 280--
Particle Size (Air Jet, 60 mesh, 250 microns)min. 10wt%-
Particle Size (Air Jet, 100 mesh, 150 microns)min. 50wt%-

Regulatory & Compliance

Certifications & Compliance Search Terms
Quality Standards

Technical Details & Test Data

Typical Nutrient Information/100g
  US EU/Australia/NZ
Estimated Caloric Value 0 Cal

194 Cal/ 811 kJoules

Calories from Fat 0 Cal 0 Cal
Total Fat 0 g 0 g
Saturated Fat 0 g 0 g
Trans-Fat 0 g 0 g
Polyunsaturated Fat 0 g 0 g
Monounsaturated Fat 0 g 0 g
Cholesterol 0 mg 0 mg
Sodium 5 mg 5 mg
Salt -g 0.01 g
Potassium 0 mg 0 mg
Total Carbohydrate 97 g 0 g
Sugars (Total) 0 g 0 g
Added Sugars 0 g 0 g
Starch 0 g 0 g
Total Dietary Fiber 97 g 97 g
Dietary Fiber (Soluble) 0 g 0 g
Dietary Fiber (Insoluble) 97 g 97 g
Protein 0 g 0 g
Vitamin A 0 mcg 0 mcg
Vitamin C 0 mg 0 mg
Vitamin D 0 mcg 0 mcg
Calcium 1 mg 1 mg
Iron 0.2 mg 0.2 mg
Magnesium 0 mg 0 mg
Moisture 3 g 3 g
Ash 0 g 0 g
Organic acid 0 g 0 g

US: Calories = [(Total Carbs + Protein) * 4 Cal/g + (Fat * 9 Cal/g)]. Soluble fiber is included in Total Carbs, but calorie contribution is calculated at 2 Cal/g. In the US, food manufacturers have the option to exclude the amount of insoluble fiber from the calorie calculation.
EU: Calories = ([Carbs (sugars + starch ) + Protein] * 4 Cal/g) + (Fat * 9 Cal/g) + (All dietary fiber * 2 Cal/g) + (Organic acids * 3 Cal/g)). In Europe, fiber is listed separately and is not included in the carb content. Other calorie conversion factors exist, none of which is relevant to this product.

Storage & Handling

Shelf Life
4 years
Shelf Life Information

Store at ambient conditions. Keep containers sealed; material is very hygroscopic. Four (4) years from date of manufacture, if storage conditions stated above are observed. IFF recommends that after the above re-evaluation date, the customer perform the loss on drying test. Typical Degree Polymerization range for Avicel PH microcrystalline cellulose is 100 to 300.